CD2: CD2 Protein | CD2 Antibody

CD2 Gene family

CD2 Background

T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.

Reference for CD2

  • Yang JJ, et al. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci. 2(1): 1-17.
  • Wilkins AL, et al. (2003) Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design. Curr Protein Pept Sci. 4(5): 367-73.
  • McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120.

CD2 Protein

CD2 protein function

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

CD2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    351.00
  • Mass (Da)
    39.00

CD2 Antibody

There are 22 CD2 antibodies which are validated in multiple tissues with various applications, including FCM, ELISA, IHC-P, WB. There are 10 CD2 antibody for FCM, 10 CD2 antibody for ELISA, 2 CD2 antibody for IHC-P, 3 CD2 antibody for WB. Among all these CD2 antibodies, there are 8 anti-CD2 mouse monoclonal antibodies , 7 anti-CD2 rabbit monoclonal antibodies , 7 anti-CD2 rabbit polyclonal antibodies . All the CD2 anbodies are produced in house and all are in stock. CD2 antibody customerized service is available.

CD2 Gene

CD2 gene / cDNA is a protein-coding gene which located on 1p13.1. The CD2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.199 organisms have orthologs with human gene CD2.