CLEC4D: CLEC4D Protein | CLEC4D Antibody

CLEC4D Gene family

CLEC4D Background

C-type lectin (CLEC) family is a type of carbohydrate-binding protein domain named lectin. C-type lectins are the most diverse and prevalent lectin family in immunity with its requirement for calcium for binding. Proteins including a C-type lectin domain have diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis. There are at least 14 types of C-type lectins: typeⅠto typeⅩⅣ. CLEC4D(CLECSF8) is a typeⅡ membrane glycoprotein belonging to the C-type lectin family, with restricted expression in the monocyte/macrophage lineage. It plays important roles in the function of macrophages.

Reference for CLEC4D

  • Johnson KD, et al. (2007) Friend of GATA-1-independent Transcriptional Repression: A Novel Mode of GATA-1 Function. Blood. 109 (12): 5230-3.
  • Arce I, et al. (2004) The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. Eur J Immunol. 34 (1): 210-20.
  • Marshall AS, et al. (2006) Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. Eur J Immunol. 36 (8): 2159-69.

CLEC4D Protein

CLEC4D protein function

A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766). Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells (PubMed:14971047). {ECO:0000250|UniProtKB:Q69FH1, ECO:0000269|PubMed:14971047, ECO:0000269|PubMed:23602766}.

CLEC4D protein expression

Tissue specificity

Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.

Induction

By autocrine inflammatory stimuli.

CLEC4D protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    215.00
  • Mass (Da)
    24.00

CLEC4D Antibody

There are 4 CLEC4D antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ELISA. There are 1 CLEC4D antibody for ELISA(Cap), 3 CLEC4D antibody for ELISA. Among all these CLEC4D antibodies, there are 1 anti-CLEC4D mouse monoclonal antibodies , 1 anti-CLEC4D rabbit monoclonal antibodies , 2 anti-CLEC4D rabbit polyclonal antibodies . All the CLEC4D anbodies are produced in house and all are in stock. CLEC4D antibody customerized service is available.

CLEC4D Gene

CLEC4D gene / cDNA is a protein-coding gene which located on 12p13.31. The CLEC4D gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.80 organisms have orthologs with human gene CLEC4D.