CLEC10A: CLEC10A Protein | CLEC10A Antibody

CLEC10A Gene family

CLEC10A Background

CLEC1A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD31) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD31 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs). There are 2 homologues: MGL1 and MGL2 (CD31a and CD31b) in mice. MGL1/CD31a induces both the production and secretion of interleukin (IL)-1. MGL1/CD31a plays a protective role against colitis by effectively inducing IL-1 production by colonic lamina propria macrophages in response to invading commensal bacteria.

Reference for CLEC10A

  • Saba K, et al. (2009) A C-type lectin MGL1/CD301a plays an anti-inflammatory role in murine experimental colitis. Am J Pathol. 174(1): 144-52.
  • Suzuki N, et al. (2002) Molecular cloning and expression of cDNA encoding human macrophage C-type lectin: its unique carbohydrate binding specificity for Tn antigen. J Immunol. 1996 ;156: 128-135.
  • Tsuiji M, et al. (2002) Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J Biol Chem. 277: 28892-28901.
  • Denda-Nagai K, et al. (2002) Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of glycosylated antigens. Glycobiology. 12: 443-450.

CLEC10A Protein

CLEC10A protein function

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. {ECO:0000269|PubMed:8598452}.

CLEC10A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

CLEC10A Antibody

There are 4 CLEC10A antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA. There are 1 CLEC10A antibody for IHC-P, 3 CLEC10A antibody for ELISA. Among all these CLEC10A antibodies, there are 3 anti-CLEC10A rabbit polyclonal antibodies , 1 anti-CLEC10A rabbit monoclonal antibodies . All the CLEC10A anbodies are produced in house and all are in stock. CLEC10A antibody customerized service is available.

CLEC10A Gene

CLEC10A gene / cDNA is a protein-coding gene which located on 17p13.1. The CLEC10A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.43 organisms have orthologs with human gene CLEC10A.