CEACAM5: CEACAM5 Protein | CEACAM5 Antibody

CEACAM5 Gene family

CEACAM5 Background

CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 18 kDa comprising 6% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.

Reference for CEACAM5

  • Baczyska D, et al. (2003) The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Cell Mol Biol Lett. 8(2): 471-86.
  • Blumenthal RD, et al. (2005) Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res. 65(19): 8809-17.
  • Liebig B, et al. (2005) Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett. 223(1): 159-67.

CEACAM5 Protein

CEACAM5 protein function

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.

CEACAM5 protein expression

Tissue specificity

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

CEACAM5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    702.00
  • Mass (Da)
    76.00

CEACAM5 Antibody

There are 17 CEACAM5 antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), FCM, ELISA(Det), ELISA, IHC-P. There are 1 CEACAM5 antibody for ELISA(Cap), 5 CEACAM5 antibody for FCM, 1 CEACAM5 antibody for ELISA(Det), 9 CEACAM5 antibody for ELISA, 2 CEACAM5 antibody for IHC-P. Among all these CEACAM5 antibodies, there are 7 anti-CEACAM5 mouse monoclonal antibodies , 8 anti-CEACAM5 rabbit monoclonal antibodies , 2 anti-CEACAM5 rabbit polyclonal antibodies . All the CEACAM5 anbodies are produced in house and all are in stock. CEACAM5 antibody customerized service is available.

CEACAM5 Gene

CEACAM5 gene / cDNA is a protein-coding gene which located on 19q13.2. The CEACAM5 gene is conserved in chimpanzee, Rhesus monkey, and zebrafish.15 organisms have orthologs with human gene CEACAM5.