CD97: CD97 Protein | CD97 Antibody

CD97 Gene family

CD97 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD97 is a receptor predominantly expressed in leukocytes and belongs to a new group of seven-span transmembrane molecules, which is also designed EGF-TM7 family. The family members are characterized by an extended extracellular region with several N-terminal epidermal growth factor-like domains two of which contain a calcium binding site. Muture CD 97 has two noncovalently associated subunits and is composed of a large extracellular protein (CD97 alpha) and a seven-membrane spanning protein (CD97 beta). CD97 is considered as a defining feature of G protein-coupled receptors. The effects that lymphocytes and erythrocytes adere to CD97-transfected COS cells suggest that CD97 has the ability to bind cellular ligands. CD97 alpha has three alternatively spliced isforms that are related to the calium binding EGF-like repeats in the microfibril protein fibrillin. Leukocytes strongly positive for CD97 are concentrated at sites of inflammation relative to CD97 expression in normal lymphoid tissues.

Reference for CD97

  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Gray JX, et al. (1996) CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. The journal of Immunology. 157 (12): 5438-47.
  • Hamann J,et al. (1998) Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97.European Journal of Immunology. 28 (5): 1701-7.

CD97 Antibody

There are 14 CD97 antibodies which are validated in multiple tissues with various applications, including WB, IP, FCM, ICC/IF, ELISA, ELISA(Det), ELISA(Cap). There are 3 CD97 antibody for WB, 3 CD97 antibody for IP, 8 CD97 antibody for FCM, 4 CD97 antibody for ICC/IF, 6 CD97 antibody for ELISA, 1 CD97 antibody for ELISA(Det), 1 CD97 antibody for ELISA(Cap). Among all these CD97 antibodies, there are 4 anti-CD97 rabbit polyclonal antibodies , 6 anti-CD97 mouse monoclonal antibodies , 4 anti-CD97 rabbit monoclonal antibodies . All the CD97 anbodies are produced in house and all are in stock. CD97 antibody customerized service is available.

CD97 Gene

ADGRE5 gene / cDNA is a protein-coding gene which located on 19p13.12. The ADGRE5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.124 organisms have orthologs with human gene ADGRE5.