CD70: CD70 Protein | CD70 Antibody

CD70 Gene family

CD70 Background

CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.

Reference for CD70

  • Adam PJ, et al. (2006) CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer. 95(3): 298-306.
  • Keller AM, et al. (2007) Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules. Proc Natl Acad Sci U S A. 104(14): 5989-94.
  • Grewal IS. (2008) CD70 as a therapeutic target in human malignancies. Expert Opin Ther Targets. 12(3): 341-51.
  • Boursalian TE, et al. (2009) Targeting CD70 for human therapeutic use. Adv Exp Med Biol. 647: 108-19.

CD70 Protein

CD70 protein function

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

CD70 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    193.00
  • Mass (Da)
    21.00

CD70 Antibody

There are 1 CD70 antibodies which are validated in multiple tissues with various applications, including WB. There are 1 CD70 antibody for WB. Among all these CD70 antibodies, there are 1 anti-CD70 rabbit polyclonal antibodies . All the CD70 anbodies are produced in house and all are in stock. CD70 antibody customerized service is available.

CD70 Gene

CD70 gene / cDNA is a protein-coding gene which located on 19p13.3. The CD70 gene is conserved in Rhesus monkey, dog, cow, mouse, and rat.108 organisms have orthologs with human gene CD70.