CD63 Protein

CD63 Protein Overview

CD63 reagents

The melanoma-associated antigen ME491 is expressed strongly during early stages of progression of the tumor. Hotta et al. (1988) cloned the ME491 gene by means of DNA-mediated gene transfer followed by the screening of a lambda genomic library with human repetitive Alu sequences as a probe. The cloned DNA, after transcription into mouse L-cells, generated a protein whose characteristics were indistinguishable in Western blot analysis from the ME491 antigen expressed by human melanoma cells. The sequence of the cDNA indicates that the antigen has 237 amino acids (molecular mass, 25,475 Da) with 4 transmembrane regions and 3 putative N-glycosylation sites.

CD63 protein family

Belongs to the tetraspanin (TM4SF) family.

CD63 protein name

Recommended name
CD63 antigen
ME491, TSPAN30
Alternative name
Granulophysin Lysosomal-associated membrane protein 3 LAMP-3 Melanoma-associated antigen ME491 OMA81H Ocular melanoma-associated antigen Tetraspanin-30 Tspan-30 CD antigen CD63

CD63 Protein Sequence

Species Human CD63 protein
Length 238
Mass (Da) 25637
Sequence Human CD63 protein sequence
Species Mouse CD63 protein
Length 238
Mass (Da) 25767
Sequence Mouse CD63 protein sequence
Species Rat CD63 protein
Length 238
Mass (Da) 25699
Sequence Rat CD63 protein sequence

CD63 Protein Molecular Weight & PI

CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 2-238 CD63 antigen.

Molecular weight (Da)


Theoretical pI


CD63 Protein Interaction

Recombinant CD63 Protein Feature

CD63 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant CD63 protein citations

Host protein CD63 enhances viral RNA replication by interacting with human astrovirus nonstructural protein nsP1a/4
zhao, w;liu, N;Tao, X;Zheng, C;Li, X;Yu, M;Li, Y;
Aptamer-based fluorescence polarization assay for separation-free exosome quantification
Zhang, Z;Tang, C;Zhao, L;Xu, L;Zhou, W;Dong, Z;Yang, Y;Xie, Q;Fang, X;

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