CD59: CD59 Protein | CD59 Antibody

CD59 Gene family

CD59 Background

CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Reference for CD59

  • Fletcher CM. et al., 1994, Structure. 2: 185-99.
  • Rudd PM. et al., 1997, J Biol Chem. 272: 7229-44.
  • Kimberley FC. et al., 2007, Mol Immunol. 44 (1-3): 73-81.
  • Gong Y. et al., 2007, Sci China C Life Sci. 50 (6): 773-9.
  • Picariello G. et al., 2008, Proteomics 8: 3833-47.
  • Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.

CD59 Protein

CD59 protein function

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

CD59 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    128.00
  • Mass (Da)
    14.00

CD59 Antibody

There are 24 CD59 antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ELISA, FCM, ELISA(Det), WB, IP. There are 2 CD59 antibody for ELISA(Cap), 9 CD59 antibody for ELISA, 13 CD59 antibody for FCM, 1 CD59 antibody for ELISA(Det), 2 CD59 antibody for WB, 2 CD59 antibody for IP. Among all these CD59 antibodies, there are 17 anti-CD59 rabbit monoclonal antibodies , 7 anti-CD59 rabbit polyclonal antibodies . All the CD59 anbodies are produced in house and all are in stock. CD59 antibody customerized service is available.

CD59 Gene

CD59 gene / cDNA is a protein-coding gene which located on 11p13. The CD59 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.197 organisms have orthologs with human gene CD59.