CD38: CD38 Protein | CD38 Antibody

CD38 Gene family

CD38 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4<sup>+</sup>, CD8<sup>+</sup>, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD<sup>+</sup> to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.

CD38 Protein

CD38 protein function

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

CD38 protein expression

Tissue specificity

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Induction

Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

CD38 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    300.00
  • Mass (Da)
    34.00

CD38 Antibody

There are 26 CD38 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM, IHC-P, WB, IP, ELISA(Cap), ICC/IF. There are 14 CD38 antibody for ELISA, 8 CD38 antibody for FCM, 8 CD38 antibody for IHC-P, 3 CD38 antibody for WB, 3 CD38 antibody for IP, 1 CD38 antibody for ELISA(Cap), 1 CD38 antibody for ICC/IF. Among all these CD38 antibodies, there are 12 anti-CD38 mouse monoclonal antibodies , 7 anti-CD38 rabbit monoclonal antibodies , 7 anti-CD38 rabbit polyclonal antibodies . All the CD38 anbodies are produced in house and all are in stock. CD38 antibody customerized service is available.

CD38 Gene

CD38 gene / cDNA is a protein-coding gene which located on 4p15.32. The CD38 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog.172 organisms have orthologs with human gene CD38.