LAMP3 / CD208: LAMP3 / CD208 Protein | LAMP3 / CD208 Antibody

LAMP3 / CD208 Gene family

LAMP3 / CD208 Background

Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD28, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm18, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.

Reference for LAMP3 / CD208

  • Salaun B, et al. (2003) Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 33(9): 2619-29.
  • Salaun B, et al. (2004) CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 164(3): 861-71.
  • Ishigami S, et al. (2010) Prognostic value of CD208-positive cell infiltration in gastric cancer. Cancer Immunol Immunother. 59(3): 389-95.

LAMP3 / CD208 Protein

LAMP3 / CD208 protein function

May play a role in dendritic cell function and in adaptive immunity. {ECO:0000269|PubMed:9768752}.

LAMP3 / CD208 protein expression

Tissue specificity

Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.

Induction

Up-regulated during dendritic cell maturation.

LAMP3 / CD208 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    416.00
  • Mass (Da)
    44.00

LAMP3 / CD208 Antibody

There are 8 LAMP3 / CD208 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ELISA, ELISA(Det), ICC/IF, ELISA(Cap). There are 2 LAMP3 / CD208 antibody for WB, 1 LAMP3 / CD208 antibody for IHC-P, 5 LAMP3 / CD208 antibody for ELISA, 1 LAMP3 / CD208 antibody for ELISA(Det), 1 LAMP3 / CD208 antibody for ICC/IF, 1 LAMP3 / CD208 antibody for ELISA(Cap). Among all these LAMP3 / CD208 antibodies, there are 4 anti-LAMP3 / CD208 rabbit polyclonal antibodies , 1 anti-LAMP3 / CD208 mouse monoclonal antibodies , 3 anti-LAMP3 / CD208 rabbit monoclonal antibodies . All the LAMP3 / CD208 anbodies are produced in house and all are in stock. LAMP3 / CD208 antibody customerized service is available.

LAMP3 / CD208 Gene

LAMP3 gene / cDNA is a protein-coding gene which located on 3q27.1. The LAMP3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.201 organisms have orthologs with human gene LAMP3.