CD1E: CD1E Protein | CD1E Antibody

CD1E Gene family

CD1E Background

CD1 is a family of proteins structurally related to major histocompatibility complex (MHC) molecules and specialized in presenting lipids or glycolipids to T cells. In humans, there are five CD1 genes (CD1A to CD1E). CD1E and CD1A genes may be involved in networks which determine susceptibility to RR-MS and PP-MS, respectively. CD1A and CD1E polymorphisms contribute to the polygenic susceptibility to MS. It's a possible role of CD1E polymorphisms in malaria protection among school children and that CD1e molecules are involved in anti-malarial immunity.

Reference for CD1E

  • Caporale CM, et al. (2011) Cd1a and cd1e gene polymorphisms are associated with susceptibility to multiple sclerosis. Int J Immunopathol Pharmacol 24(1), 175-183.
  • Jamshidian A, et al. (2010) Association of cd1a +622 t/c, +737 g/c and cd1e +6129 a/g genes polymorphisms with multiple sclerosis. Immunol Invest 39(8), 874-889.
  • Mirones I, et al. (2000) Identification of two novel human cd1e alleles. Tissue Antigens 56(2), 159-161.
  • Mombo LE, et al. (2017) Homozygosity for the cd1e*02 allele is associated with a resistance to plasmodium falciparum malaria infection in gabonese school children. Asian Pac J Trop Med 10(2), 204-207.

CD1E Protein

CD1E protein function

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. {ECO:0000269|PubMed:10948205, ECO:0000269|PubMed:16311334, ECO:0000269|PubMed:21788486}.

CD1E protein expression

Tissue specificity

Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.

CD1E protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    388.00
  • Mass (Da)
    43.00

CD1E Antibody

There are 1 CD1E antibodies which are validated in multiple tissues with various applications, including WB. There are 1 CD1E antibody for WB. Among all these CD1E antibodies, there are 1 anti-CD1E rabbit polyclonal antibodies . All the CD1E anbodies are produced in house and all are in stock. CD1E antibody customerized service is available.

CD1E Gene

CD1E gene / cDNA is a protein-coding gene which located on 1q23.1. The CD1E gene is conserved in chimpanzee, Rhesus monkey, dog, and cow.51 organisms have orthologs with human gene CD1E.