CD160 cDNA Clone: Expression and Clone Vector / Plasmid

CD160 cDNA / Gene Overview

CD160 gene / cDNA is a protein-coding gene which located on 1q21.1. The CD160 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, and rat.99 organisms have orthologs with human gene CD160.

CD160 cDNA / Gene Function

CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]

CD160 cDNA / Gene Sequence

LOCUS
LOCUS NM_007053 1633 bp mRNA linear PRI 30-JUN-2018
DEFINITION
Homo sapiens CD160 molecule (CD160), transcript variant 1, mRNA.
ACCESSION
NM_007053
VERSION
NM_007053.3

This sequence information is just for reference only.

CD160 Family & Reagents

CD160 Gene family reagents (CD molecules)

Approved Symbol Reagent list
IL21R
LILRB3
IL2RG
TNFRSF1A
PROM1
PDGFRB
CLEC12A
IL13Ra2
CD82
CD28
Approved Symbol Reagent list
SIRPA
B3gat1
CD58
SLAMF1
TNFRSF13B
CD6
FCER2
IL10RB
SDC1
GYPA

CD160 Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
BTLA
IL18R1
KDR
FCRL2
CNTN1
CNTFR
BSG
CNTN3
IL6R
CLMP
Approved Symbol Reagent list
IL12B
NTRK1
F11R
CD244
SEMA3A
NECTIN1
IL1RL1
AGER
MUSK
IL1R1

CD160 cDNA / Gene Alias

  • BY55
  • NK1
  • NK28

CD160 cDNA / Gene Expression

Biased expression in spleen (RPKM 5.2), duodenum (RPKM 1.7) and 12 other tissues