PVR gene / cDNA is a protein-coding gene which located on 19q13.31. The PVR gene is conserved in chimpanzee, Rhesus monkey, dog, and cow.69 organisms have orthologs with human gene PVR.
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
CD155 / PVR cDNA / Gene Sequence
LOCUS
LOCUS NM_006505 5903 bp mRNA linear PRI 23-JUL-2018
DEFINITION
Homo sapiens poliovirus receptor (PVR), transcript variant 1, mRNA.
ACCESSION
NM_006505
VERSION
NM_006505.4
This sequence information is just for reference only.
Ubiquitous expression in adrenal (RPKM 7.2), placenta (RPKM 6.6) and 25 other tissues
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