CD155 / PVR: CD155 / PVR Protein | CD155 / PVR Antibody

CD155 / PVR Gene family

CD155 / PVR Background

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

Reference for CD155 / PVR

  • Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
  • Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
  • Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
  • Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
  • Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.

CD155 / PVR Protein

CD155 / PVR protein function

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. {ECO:0000269|PubMed:15471548, ECO:0000269|PubMed:15607800}.; (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. {ECO:0000269|PubMed:2538245}.; (Microbial infection) Acts as a receptor for Pseudorabies virus. {ECO:0000269|PubMed:9616127}.; (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. {ECO:0000269|PubMed:15640804}.

CD155 / PVR protein expression

Induction

Transcriptionally regulated by SHH.

CD155 / PVR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    417.00
  • Mass (Da)
    45.00

CD155 / PVR Antibody

There are 24 CD155 / PVR antibodies which are validated in multiple tissues with various applications, including FCM, ICC/IF, WB, ELISA, IP. There are 9 CD155 / PVR antibody for FCM, 2 CD155 / PVR antibody for ICC/IF, 5 CD155 / PVR antibody for WB, 15 CD155 / PVR antibody for ELISA, 2 CD155 / PVR antibody for IP. Among all these CD155 / PVR antibodies, there are 7 anti-CD155 / PVR mouse monoclonal antibodies , 9 anti-CD155 / PVR rabbit monoclonal antibodies , 8 anti-CD155 / PVR rabbit polyclonal antibodies . All the CD155 / PVR anbodies are produced in house and all are in stock. CD155 / PVR antibody customerized service is available.

CD155 / PVR Gene

PVR gene / cDNA is a protein-coding gene which located on 19q13.31. The PVR gene is conserved in chimpanzee, Rhesus monkey, dog, and cow.69 organisms have orthologs with human gene PVR.