CD137 Protein

CD137 Protein Overview

CD137 reagents

ILA is a member of the tumor necrosis factor (TNF) receptor family (see 191190). Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiologic processes and play an important role in the regulation of immune responses. ILA is expressed by activated T and B lymphocytes and monocytes.

CD137 protein name

Recommended name
Tumor necrosis factor receptor superfamily member 9
Aliases
4-1BB, CD137
Alternative name
4-1BB ligand receptor CDw137 T-cell antigen 4-1BB homolog T-cell antigen ILA CD_antigen: CD137

CD137 Gene family protein

CD137 Protein Sequence

Species Human CD137 protein
Length 255
Mass (Da) 27899
Sequence Human CD137 protein sequence
Species Mouse CD137 protein
Length 256
Mass (Da) 27598
Sequence Mouse CD137 protein sequence
Species
Length
Mass (Da)
Sequence

CD137 Protein Molecular Weight & PI

Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD137 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 24-255 Tumor necrosis factor receptor

Molecular weight (Da)

25301.85

Theoretical pI

7.99

CD137 Protein Structure

Crystal structure of 4-1BBL/4-1BB complex in C2 space group
Deposited
2018-03-14   Released:  2018-05-09
Deposition Author(s)
Aruna, B., Zajonc, D.M.
Organism(s)
Homo sapiens
Expression System
Insect cell expression vector pTIE1
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.7000 Å
R-Value Free
0.280
R-Value Work
0.249
6CPR From PDB

Human CD137 protein Secondary structure

CD137 Protein Interaction

Recombinant CD137 Protein Feature

CD137 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1.Measured by its binding ability in a functional ELISA. 2.Immobilized human TNFRSF9 (Cat:10041-H08H) at 10μg/mL (100μL/well) can bind human TNFSF9 (Cat:15693-H01H),the EC50 of human TNFSF9 is 7-40ng/mL.

Recombinant CD137 protein citations

Title
Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands
Year
2014
Author
Yi, L;Zhao, Y;Wang, X;Dai, M;Hellström, KE;Hellström, I;Zhang, H;
Journal
PLoS ONE
Title
A potent in vivo anti-tumor efficacy of novel recombinant type I interferon
Year
2016
Author
Zhang, K;Yin, XF;Yang, YQ;Li, HL;Xu, YN;Chen, LY;Liu, XJ;Yuan, SJ;Fang, XL;Xiao, J;Wu, S;Xu, H;Chu, L;Katlinski, KV;Katlinskaya, YV;Guo, RB;Wei, GW;Wang, DC;Liu, X;Fuchs, SY;
Journal
Clin. Cancer Res.
Title
A potent in vivo anti-tumor efficacy of novel recombinant type I interferon
Year
2016
Author
Zhang, K;Yin, XF;Yang, YQ;Li, HL;Xu, YN;Chen, LY;Liu, XJ;Yuan, SJ;Fang, XL;Xiao, J;Wu, S;Xu, H;Chu, L;Katlinski, KV;Katlinskaya, YV;Guo, RB;Wei, GW;Wang, DC;Liu, X;Fuchs, SY;
Journal
Clin. Cancer Res.
Title
CD137-CRDI is not necessary in the role of contacting its natural ligand
Year
2016
Author
Yi, L;Yan, Z;Jia, H;Wang, X;Zhao, Y;Zhang, H;
Journal
Immunol. Cell Biol.

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