IL3RA: IL3RA Protein | IL3RA Antibody

IL3RA Gene family

IL3RA Background

Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and / or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.

Reference for IL3RA

  • Del Giudice I, et al. (2004) The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica. 89(3): 303-8.
  • Du X, et al. (2007) New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. J Immunother. 30(6): 607-13.
  • Yue LZ, et al. (2010) Expression of CD123 and CD114 on the bone marrow cells of patients with myelodysplastic syndrome. Chin Med J (Engl). 123(15): 2034-2037.

IL3RA Protein

IL3RA protein function

This is a receptor for interleukin-3.

IL3RA protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

IL3RA Antibody

There are 8 IL3RA antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ELISA, FCM, ELISA(Det), WB, IP. There are 1 IL3RA antibody for ELISA(Cap), 5 IL3RA antibody for ELISA, 2 IL3RA antibody for FCM, 1 IL3RA antibody for ELISA(Det), 1 IL3RA antibody for WB, 1 IL3RA antibody for IP. Among all these IL3RA antibodies, there are 4 anti-IL3RA mouse monoclonal antibodies , 2 anti-IL3RA rabbit monoclonal antibodies , 2 anti-IL3RA rabbit polyclonal antibodies . All the IL3RA anbodies are produced in house and all are in stock. IL3RA antibody customerized service is available.

IL3RA Gene

IL3Ra gene / cDNA is a protein-coding gene which located on Xp22.3 and Yp13.3. The IL3RA gene is conserved in chimpanzee, dog, cow, mouse, and rat.73 organisms have orthologs with human gene IL3RA.