CCR6: CCR6 Protein | CCR6 Antibody

CCR6 Gene family

CCR6 Background

Chemokine receptors CCR6 and CCR7 have been reported to play important roles in T cell migration and organ-specific metastasis of various tumors. The expression levels of CCR6 and CCR7 in tumor tissues in patients with lymph node metastases than those without lymph node metastases. CCR6 and CCR7 expressions were also detected in metastatic lymph nodes. CCR6(+) subset of CD4(+) regulatory T cells, a newly characterized subset of Tregs, has been reported to contribute to local immune inhibition. There is a new subset of tumor-resident Tregs, CCR6(+) Tregs, may be dominantly responsible for the immunosuppression in tumor immunity and a potential predictor of the poor prognosis of breast cancer.

Reference for CCR6

  • Chen B, et al. (2010) [expression and clinical significance of ccr6, ccr7 and cd4(+)cd25(+) foxp3(+) regulatory t cells in laryngeal squamous cell carcinoma and neck lymphatic metastasis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 45(9), 759-764.
  • Chen B, et al. (2013) High ccr6/ccr7 expression and foxp3+ treg cell number are positively related to the progression of laryngeal squamous cell carcinoma. Oncol Rep 30(3), 1380-1390.
  • Xu L, et al. (2010) Enrichment of ccr6+foxp3+ regulatory t cells in the tumor mass correlates with impaired cd8+ t cell function and poor prognosis of breast cancer. Clin Immunol 135(3), 466-475.

CCR6 Protein

CCR6 protein function

Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988). {ECO:0000250|UniProtKB:O54689, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:9169459, ECO:0000303|PubMed:21376174, ECO:0000303|PubMed:25585877}.

CCR6 protein expression

Tissue specificity

Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.


By IL2/interleukin-2.

CCR6 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

CCR6 Antibody

There are 2 CCR6 antibodies which are validated in multiple tissues with various applications, including WB. There are 2 CCR6 antibody for WB. Among all these CCR6 antibodies, there are 2 anti-CCR6 rabbit polyclonal antibodies . All the CCR6 anbodies are produced in house and all are in stock. CCR6 antibody customerized service is available.

CCR6 Gene

CCR6 gene / cDNA is a protein-coding gene which located on 6q27. The CCR6 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.209 organisms have orthologs with human gene CCR6.