Caspase-14 cDNA Clone: Expression and Clone Vector / Plasmid
Caspase-14 cDNA / Gene Overview
CASP14 gene / cDNA is a protein-coding gene which located on 19p13.12. The CASP14 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.115 organisms have orthologs with human gene CASP14.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]
Caspase-14 cDNA / Gene Sequence
LOCUS NM_012114 3153 bp mRNA linear PRI 25-JUN-2018
Homo sapiens caspase 14 (CASP14), mRNA.
This sequence information is just for reference only.
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