Caspase-14 cDNA Clone: Expression and Clone Vector / Plasmid

Caspase-14 cDNA / Gene Overview

CASP14 gene / cDNA is a protein-coding gene which located on 19p13.12. The CASP14 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.115 organisms have orthologs with human gene CASP14.

Caspase-14 cDNA / Gene Function

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]

Caspase-14 cDNA / Gene Sequence

LOCUS
LOCUS NM_012114 3153 bp mRNA linear PRI 25-JUN-2018
DEFINITION
Homo sapiens caspase 14 (CASP14), mRNA.
ACCESSION
NM_012114
VERSION
NM_012114.2

This sequence information is just for reference only.

Caspase-14 Family & Reagents

Gene family

Caspase-14 Gene family reagents (Caspases)

Approved Symbol Reagent list
CASP3
Approved Symbol Reagent list
CASP7

Caspase-14 cDNA / Gene Alias

  • apoptosis-related cysteine protease
  • MGC119078
  • MGC119079
  • MICE

Caspase-14 cDNA / Gene Expression

Restricted expression toward skin (RPKM 223.1)