C1 inhibitor cDNA Clone: Expression and Clone Vector / Plasmid

C1 inhibitor cDNA / Gene Overview

SerpinG1 gene / cDNA is a protein-coding gene which located on 11q12.1. The SERPING1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.162 organisms have orthologs with human gene SERPING1.

C1 inhibitor cDNA / Gene Function

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

C1 inhibitor cDNA / Gene Sequence

LOCUS
LOCUS NM_000062 1984 bp mRNA linear PRI 16-JUL-2018
DEFINITION
Homo sapiens serpin family G member 1 (SERPING1), transcript variant 1, mRNA.
ACCESSION
NM_000062
VERSION
NM_000062.2

This sequence information is just for reference only.

C1 inhibitor Family & Reagents

C1 inhibitor Gene family reagents (Serpin peptidase inhibitors)

Approved Symbol Reagent list
SerpinF2
SerpinA3
SerpinE1
SerpinB2
SerpinF1
SerpinB6
SerpinA10
SerpinB8
SerpinI2
AGT
Approved Symbol Reagent list
SerpinA6
SerpinB10
SerpinA11
SerpinB1
SERPINB4
SerpinB9
SerpinI1
SERPINB3
SerpinA12
SERPINA7

C1 inhibitor cDNA / Gene Alias

  • angioedema
  • hereditary
  • C1IN
  • C1-INH
  • HAE1
  • HAE2
  • plasma protease C1 inhibitor

C1 inhibitor cDNA / Gene Expression

Broad expression in liver (RPKM 710.5), gall bladder (RPKM 322.8) and 17 other tissues