BTLA: BTLA Protein | BTLA Antibody

BTLA Gene family

BTLA Background

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

Reference for BTLA

  • Fourcade J, et al. (2012) CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 72(4):887-96.
  • Kojima R, et al. (2011) Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol. 413(4):762-72.
  • Oki M, et al. (2011) A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol. 305656.

BTLA Protein

BTLA protein function

Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. {ECO:0000269|PubMed:12796776}.

BTLA protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    289.00
  • Mass (Da)
    32.00

BTLA Antibody

There are 3 BTLA antibodies which are validated in multiple tissues with various applications, including WB. There are 3 BTLA antibody for WB. Among all these BTLA antibodies, there are 3 anti-BTLA rabbit polyclonal antibodies . All the BTLA anbodies are produced in house and all are in stock. BTLA antibody customerized service is available.

BTLA Gene

BTLA gene / cDNA is a protein-coding gene which located on 3q13.2. The BTLA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog.183 organisms have orthologs with human gene BTLA.