BMP-2 Protein

BMP-2 Protein Overview

BMP-2 reagents

The transforming growth factor-beta (TGFB) superfamily encodes at least 12 members, including TGFB1 (190180), TGFB2 (190220), TGFB3 (190230), mullerian inhibitory substance (600957), the bone morphogenetic proteins-2A, -2B (BMP4; 112262), -3 (112263), and -6 (112266). Wozney et al. (1988) purified bone morphogenetic proteins BMP2A and BMP3 from demineralized bone on the basis of their ability to induce the formation of ectopic cartilage when implanted subcutaneously.

BMP-2 protein family

Belongs to the TGF-beta family.

BMP-2 protein name

Recommended name
Bone morphogenetic protein 2
Short name
BMP-2
Alternative name
Bone morphogenetic protein 2A BMP-2A

BMP-2 Protein Sequence

Species Human BMP-2 protein
Length 396
Mass (Da) 44702
Sequence Human BMP-2 protein sequence
Species Mouse BMP-2 protein
Length 394
Mass (Da) 44525
Sequence Mouse BMP-2 protein sequence
Species Rat BMP-2 protein
Length 393
Mass (Da) 44383
Sequence Rat BMP-2 protein sequence

BMP-2 Protein Molecular Weight & PI

Bone morphogenetic protein 2 precursor (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 283-396 Bone morphogenetic protein 2.

Molecular weight (Da)

12904.83

Theoretical pI

8.21

BMP-2 Protein Structure

COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS
Deposited
2000-04-07   Released:  2000-10-07
Deposition Author(s)
Kirsch, T., Sebald, W., Dreyer, M.K.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.9000 Å
R-Value Free
0.229
R-Value Work
0.191
1ES7 From PDB

Human BMP-2 protein Secondary structure

BMP-2 Protein Interaction

Recombinant BMP-2 Protein Feature

BMP-2 Protein, Human, Recombinant

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.
High Activity
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.1-0.5μg/mL.

Recombinant BMP-2 protein citations

Title
Serum regulation of Id1 expression by a BMP pathway and BMP responsive element
Year
2013
Author
Lewis, TC;Prywes, R;
Journal
Biochim. Biophys. Acta
Title
Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
Year
2013
Author
TC Lewis
Journal
the degree of Doctor of Philosophy in the Graduate School of Arts and Sciences
Title
Recombinant human bone morphogenetic protein-2-induced ossification of the ligamentum flavum in rats and the associated global modification of histone H3
Year
2014
Author
Hou, XF;Fan, DW;Sun, CG;Chen, ZQ;
Journal
J Neurosurg Spine
Title
Characterization of BMP signaling dependent osteogenesis using a BMP depletable avianized bone marrow stromal cell line (TVA-BMSC)
Year
2016
Author
Yadav, PS;Khan, MP;Prashar, P;Duggal, S;Rath, SK;Chattopadhyay, N;Bandyopadhyay, A;
Journal
Bone
Title
Small molecule T63 suppresses osteoporosis by modulating osteoblast differentiation via BMP and WNT signaling pathways
Year
2017
Author
Zhao, XL;Chen, JJ;Zhang, GN;Wang, YC;Si, SY;Chen, LF;Wang, Z;
Journal
Sci Rep
Title
Heterologous Secretory Expression and Characterization of Dimerized Bone Morphogenetic Protein 2 in Bacillus subtilis
Year
2017
Author
Hanif, MU;Gul, R;Hanif, MI;Hashmi, AA;
Journal
BioMed Research International
Title
Small Ubiquitin-Like Modifier Protein 3 Enhances the Solubilization of Human Bone Morphogenetic Protein 2 in E. coli
Year
2018
Author
Hanif, MU;Yaseen, A;Gul, R;Mirza, MU;Nawaz, MH;Ahmed, SS;Aziz, S;Chaudhary, S;Khan, AA;Shoaib, M;
Journal
Appl. Biochem. Biotechnol.
Title
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ
Year
2018
Author
Zhang, Z;Du, J;Wang, S;Shao, L;Jin, K;Li, F;Wei, B;Ding, W;Fu, P;van Dam, H;Wang, A;Jin, J;Ding, C;Yang, B;Zheng, M;Feng, XH;Guan, KL;Zhang, L;
Journal
Mol. Cell

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