Anti-ASGR2 Antibody

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Anti-ASGR2 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-ASGR2 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human ASGR2
Immunogen
Recombinant Human ASGR2 / ASGPR2 protein (Catalog#13908-H07H)
Preparation
Produced in rabbits immunized with purified, recombinant Human ASGR2 / ASGPR2 (rh ASGR2 / ASGPR2; Catalog#13908-H07H; P07307-1; Gln80-Ala311). ASGR2 / ASGPR2 specific IgG was purified by Human ASGR2 / ASGPR2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ASGR2 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ASGR2 Antibody (Rabbit Polyclonal antibody) Images

Immunochemical staining of human ASGR2 in human liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-ASGR2 Antibody: Alternative Names

Anti-ASGP-R2 Antibody; Anti-ASGPR2 Antibody; Anti-CLEC4H2 Antibody; Anti-HBXBP Antibody; Anti-HL-2 Antibody

ASGR2 Background Information

ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is a glycoprotein. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit.
Full Name
asialoglycoprotein receptor 2
References
  • Davila S, et al. (2010) New genetic associations detected in a host response study to hepatitis B vaccine. Genes Immun. 11(3):232-8.
  • Zhang X, et al. (2011) Asialoglycoprotein receptor interacts with the preS1 domain of hepatitis B virus in vivo and in vitro. Arch Virol. 156(4):637-45.
  • Guy CS, et al. (2011) Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor. Hepatology. 54(3):1043-50.

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