Anti-Von Willebrand Factor / vWF Antibody

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Anti-Von Willebrand Factor / vWF Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-Von Willebrand Factor / vWF Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Von Willebrand Factor / vWF
Immunogen
Recombinant Human VWF/Von Willebrand Factor Protein (Catalog#10973-H08C)
Preparation
Produced in rabbits immunized with purified, recombinant Human VWF/Von Willebrand Factor (rh VWF/Von Willebrand Factor; Catalog#10973-H08C; NP_000543.2; Met1-Lys2813). VWF/Von Willebrand Factor specific IgG was purified by Human VWF/Von Willebrand Factor affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Anti-Von Willebrand Factor / vWF Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Von Willebrand Factor / vWF Antibody (Rabbit Polyclonal antibody) Images

Immunochemical staining of human VWF in human tonsil with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
Immunochemical staining of human VWF in human colon with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.

Anti-Von Willebrand Factor / vWF Antibody: Alternative Names

Anti-F8VWF Antibody; Anti-Von Willebrand Factor Antibody; Anti-VWD Antibody

Von Willebrand Factor / vWF Background Information

Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.
Full Name
von Willebrand factor
References
  • Sadler JE. (1998) Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem, 67: 395-424.
  • Batlle J, et al. (2009) Von Willebrand factor/factor VIII concentrates in the treatment of von Willebrand disease. Blood Coagul Fibrinolysis. 20(2):89-100.
  • Sadler JE. (2009) von Willebrand factor assembly and secretion. J Thromb Haemost. 7 Suppl 1:24-7.
  • Auton M, et al. (2010) The mechanism of VWF-mediated platelet GPIbalpha binding. Biophys J. 99(4):1192-201.
  • Bowen DJ. (2010) Sugar targets VWF for the chop. Blood. 115(13):2565.
  • Lpez JA, et al. (2010) VWF self-association: more bands for the buck. Blood. 116(19):3693-4.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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