Anti-CD27 Antibody

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD7 on lymphocytes and dendritic cells. The CD27-CD7 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

• Cancer Immunotherapy
• Co-stimulatory Immune Checkpoint Targets
• Immune Checkpoint
• Immune Checkpoint Detection: Antibodies
• Immune Checkpoint Detection: ELISA Antibodies
• Immune Checkpoint Detection: FCM Antibodies
• Immune Checkpoint Detection: ICC Antibodies
• Immune Checkpoint Detection: IHC Antibodies
• Immune Checkpoint Proteins
• Immune Checkpoint Targets
• Immunotherapy
• Targeted Therapy

CD27 molecule

• Stem Cells>>Cancer Stem Cells (CSCs)>>Cancer Stem Cell (CSC) Marker
• Immunology>>Cluster of Differentiation (CD)>>T Cell CD Antigen>>CD Antigen (Regulatory T Cells)
• Cancer>>Cancer immunology>>CD marker
• Immune Checkpoint>>Co-stimulatory Immune Checkpoint
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Co-stimulatory Molecules
• Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>Costimulatory TNF Superfamily Molecules
• Immunology>>Cluster of Differentiation (CD)>>Natural Killer (NK) Cell CD Antigen
• Immunology>>Cluster of Differentiation (CD)>>Monocyte/Macrophage CD Antigen>>Other Monocytes/Macrophages CD Antigen
• Cancer>>Signal Transduction>>Signaling Pathway>>Representative pathway>>Apoptosis Signaling pathway>>Regulation of Apoptosis by TNF Superfamily Members
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>Processes Regulated by TNF Superfamily Members>>Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>Processes Regulated by TNF Superfamily Members>>Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>Processes Regulated by TNF Superfamily Members>>Regulation of T Cell Co-stimulation by TNF Superfamily Members
• Immunology>>Adaptive Immunity>>Regulatory T Cells
• Immunology>>Cluster of Differentiation (CD)>>T Cell CD Antigen
• Stem Cells>>Hematopoietic Progenitors>>Lymphoid>>T Lymphocytic Lineage
• Immunology>>Innate Immunity>>Cytokine>>TNF
• Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Tumor Necrosis Factor (TNF) & Receptor>>TNF Receptor
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>TNF Superfamily Receptors

• Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
• Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
• Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.