ACVR2B cDNA Clone: Expression and Clone Vector / Plasmid

ACVR2B cDNA / Gene Overview

ACVR2B gene / cDNA is a protein-coding gene which located on 3p22.2. The ACVR2B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.216 organisms have orthologs with human gene ACVR2B.

ACVR2B cDNA / Gene Function

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

ACVR2B cDNA / Gene Sequence

LOCUS
LOCUS NM_001106 11373 bp mRNA linear PRI 23-JUN-2018
DEFINITION
Homo sapiens activin A receptor type 2B (ACVR2B), mRNA.
ACCESSION
NM_001106
VERSION
NM_001106.3

This sequence information is just for reference only.

ACVR2B Family & Reagents

ACVR2B Gene family reagents (Type 2 receptor serine/threonine kinases)

Approved Symbol Reagent list
ACVR2A
TGFBR2
Approved Symbol Reagent list
BMPR2
   

ACVR2B cDNA / Gene Alias

  • ActR-IIB

ACVR2B cDNA / Gene Expression

Ubiquitous expression in testis (RPKM 1.5), brain (RPKM 1.3) and 25 other tissues

Recombinant ACVR2B protein citations

Title
A validated, sensitive electrophoretic method for the detection of activin receptor type II-Fc fusion proteins in human blood
Year
2018
Author
Martin, L;Zouhiri, N;Audran, M;Marchand, A;
Journal
Drug Test Anal
Title
Updated protocols for the detection of Sotatercept and Luspatercept in human serum
Year
2018
Author
Reichel, C;Gmeiner, G;Walpurgis, K;Thevis, M;
Journal
Drug Test Anal