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Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de expressão)

Folha de dadosAnálisesProdutos relacionadosProtocolos
Human TXN2 Informações sobre o produto de clone de cDNA
Gene_bank_ref_id:BC013726
Tamanho de cDNA:501bp
Descrição de cDNA:Full length Clone DNA of Homo sapiens thioredoxin 2.
Sinónimo de gene:MTRX, TRX2, MT-TRX
Espécie:Human
Vetor:pGEM-T Vector
Plasmid:pGEM-TXN2
Local de restrição:
Sequência de etiqueta:
Descrição da sequência:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:SP6 and T7 or M13-47 and RV-M
Promoter:
Application:
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Armazenamento:The lyophilized plasmid can be stored at room temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de expressão) on other vectors
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-GFPSpark EtiquetaHG12557-ACG$225
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-OFPSpark EtiquetaHG12557-ACR$225
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-GFPSpark EtiquetaHG12557-ANG$225
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-OFPSpark EtiquetaHG12557-ANR$225
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Flag EtiquetaHG12557-CF$195
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-His EtiquetaHG12557-CH$195
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Myc EtiquetaHG12557-CM$195
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-HA EtiquetaHG12557-CY$195
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Flag EtiquetaHG12557-NF$195
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-His EtiquetaHG12557-NH$195
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Myc EtiquetaHG12557-NM$195
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-HA EtiquetaHG12557-NY$195
Humano Thioredoxin-2/TXN2 clonagem de ADN ou de clonagem do gene (vector de clonagem)HG12557-UT$195
 Saiba mais sobre vectores de expressão
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Fundo

Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.

Referências
  • Chen Y., et al., 2002, J. Biol. Chem. 277: 33242-8.
  • Smeets A., et al., 2005, Protein Sci. 14: 2610-21.
  • Wen,S. et al., 2009, Am J Med Genet A  149A (2): 155-60.
  • Choudhary C., et al., 2009, Science 325: 834-40.
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