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TROP-2 / TACSTD2 Anticorpo, Anticorpo monoclonal de coelho, Antigen purificação por afinidade

  • TROP-2 / TACSTD2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • TROP-2 / TACSTD2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Rato TACSTD2 Informação sobre produtos de anticorpos
Imunogénio:Recombinant Mouse TROP-2 / TACSTD2 protein (Catalog#50922-M08H)
Clone ID:
Tipo Ig:Rabbit IgG
Concentração:
Endotoxina:
Formulação:0.2 μm filtered solution in PBS with 5% trehalose
Preparação:Produced in rabbits immunized with purified, recombinant Mouse TROP-2 / TACSTD2 (rM TROP-2 / TACSTD2; Catalog#50922-M08H; Q8BGV3; Met1-Gln270). TROP-2 / TACSTD2 specific IgG was purified by Mouse TROP-2 / TACSTD2 affinity chromatography.
Rato TACSTD2 Antibody IHC Application Image
TROP-2 / TACSTD2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse TACSTD2 in mouse kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
TROP-2 / TACSTD2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse TACSTD2 in mouse lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other TACSTD2 Antibody Products

Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

Lane A: NIH3T3 Whole Cell Lysate

Lane B: Hela Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:15 kDa

Observed band size:17 kDa

TROP-2/TACSTD2/TACD2 Fundo

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

Rato TROP-2/TACSTD2/TACD2 Referências
  • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
  • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.
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    Catálogo: 50922-RP02-50
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    Datasheet & Documentation

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