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TROP-2 / TACSTD2 Anticorpo, Anticorpo monoclonal de coelho, Antigen purificação por afinidade

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Mouse TACSTD2 Informação sobre produtos de anticorpos
Imunogénio:Recombinant Mouse TROP-2 / TACSTD2 protein (Catalog#50922-M08H)
Clone ID:
Tipo Ig:Rabbit IgG
Concentração:
Endotoxina:
Formulação:0.2 μm filtered solution in PBS with 5% trehalose
Preparação:Produced in rabbits immunized with purified, recombinant Mouse TROP-2 / TACSTD2 (rM TROP-2 / TACSTD2; Catalog#50922-M08H; Q8BGV3; Met1-Gln270). TROP-2 / TACSTD2 specific IgG was purified by Mouse TROP-2 / TACSTD2 affinity chromatography.
Mouse TACSTD2 Guia de utilização de anticorpos
Especificidade:Mouse TROP-2 / TACSTD2
Aplicação:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse TROP-2 / TACSTD2. The detection limit for Mouse TROP-2 / TACSTD2 is approximately 0.00975 ng/well.

IHC-P: 0.1-2 μg/mL

Armazenamento:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse TACSTD2 Antibody IHC Application Image
TROP-2 / TACSTD2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse TACSTD2 in mouse kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
TROP-2 / TACSTD2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse TACSTD2 in mouse lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other TACSTD2 Antibody Products
TROP-2/TACSTD2/TACD2 Fundo

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

Mouse TROP-2/TACSTD2/TACD2 Referências
  • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
  • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.
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    • TROP-2 / TACSTD2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
    • TROP-2 / TACSTD2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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