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Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-HA Etiqueta

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Rat CD6 Informações sobre o produto de clone de cDNA
Gene_bank_ref_id:NM_175577.3
Tamanho de cDNA:1998bp
Descrição de cDNA:Full length Clone DNA of Rattus norvegicus Cd6 molecule with C terminal HA tag.
Sinónimo de gene:OX52, MGC108551, Cd6
Espécie:Rat
Vetor:pCMV3-C-HA
Plasmid:
Local de restrição:
Sequência de etiqueta:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Descrição da sequência:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Armazenamento:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-HA Etiqueta on other vectors
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-GFPSpark EtiquetaRG80311-ACG$245
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-OFPSpark EtiquetaRG80311-ACR$245
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Flag EtiquetaRG80311-CF$215
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-His EtiquetaRG80311-CH$215
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Myc EtiquetaRG80311-CM$215
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-HA EtiquetaRG80311-CY$215
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de expressão)RG80311-G$75
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Flag EtiquetaRG80311-NF$215
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-His EtiquetaRG80311-NH$215
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Myc EtiquetaRG80311-NM$215
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-HA EtiquetaRG80311-NY$215
Ratazana CD6 / Cluster of Differentiation 6 clonagem de ADN ou de clonagem do gene (vector de clonagem)RG80311-UT$215
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Fundo

T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

Referências
  • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
  • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
  • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
  • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.
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