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Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), N-His Etiqueta

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Mouse ALOX5AP Informações sobre o produto de clone de cDNA
Gene_bank_ref_id:NM_009663.1
Tamanho de cDNA:486bp
Descrição de cDNA:Full length Clone DNA of Mus musculus arachidonate 5-lipoxygenase activating protein with N terminal His tag.
Sinónimo de gene:Flap
Espécie:Mouse
Vetor:pCMV3-N-His
Plasmid:
Local de restrição:
Sequência de etiqueta:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Descrição da sequência:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Armazenamento:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), N-His Etiqueta on other vectors
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), C-GFPSpark EtiquetaMG52815-ACG$225
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), C-OFPSpark EtiquetaMG52815-ACR$225
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), N-GFPSpark EtiquetaMG52815-ANG$225
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), N-OFPSpark EtiquetaMG52815-ANR$225
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Flag EtiquetaMG52815-CF$195
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), C-His EtiquetaMG52815-CH$195
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Myc EtiquetaMG52815-CM$195
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), C-HA EtiquetaMG52815-CY$195
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de expressão)MG52815-G$75
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Flag EtiquetaMG52815-NF$195
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), N-His EtiquetaMG52815-NH$195
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Myc EtiquetaMG52815-NM$195
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem), N-HA EtiquetaMG52815-NY$195
Ratazanao ALOX5AP / 5-lipoxygenase-activating Proteína clonagem de ADN ou de clonagem do gene (vector de clonagem)MG52815-UT$195
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Fundo

Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk for myocardial infarction, stroke and restenosis, reigniting pharmaceutical interest in this target. It had been found that ALOX5AP/FLAP is a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell line. In addition, the protein FLAP has recently been identified as an emerging target in metabolic disease. In fact, FLAP is overexpressed in the adipose tissue of patients and experimental animals with obesity.

Referências
  • Gonsalves CS, et al. (2010) Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p. J Immunol. 184(7): 3878-88.
  • Zintzaras E, et al. (2009) Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. Am J Epidemiol. 169(5): 523-32.
  • Evans JF, et al. (2008) What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol Sci. 29(2): 72-8.
  • Bck M, et al. (2007) 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Circ Res. 100: 946-9.
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