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MMP-2 Anticorpo, Anticorpo monoclonal de coelho

    Folha de dadosAnálisesProdutos relacionadosProtocolos
    Humano MMP-2 Informação sobre produtos de anticorpos
    Imunogénio:Recombinant Human MMP-2 protein (Catalog#10082-HNAH)
    Clone ID:029
    Tipo Ig:Rabbit IgG
    Concentração:
    Endotoxina:
    Formulação:0.2 μm filtered solution in PBS
    Preparação:This antibody was obtained from a rabbit immunized with purified, recombinant Human MMP-2 (rh MMP-2; Catalog#10082-HNAH; NP_004521.1; Met 1-Cys660).
    Other MMP-2 Antibody Products
    MMP2/MMP-2/CLG4A Fundo

    Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.

    Humano MMP2/MMP-2/CLG4A Referências
  • Thompson EW, et al. (1994) Collagen induced MMP-2 activation in human breast cancer. Breast Cancer Res Treat. 31(2-3): 357-70.
  • Jezierska A, et al. (2009) Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit. 15(2): RA32-40.
  • Fredrich M, et al. (2010) MMP-2 is involved in synaptic remodeling after cochlear lesion. Neuroreport. 21(5): 324-7.
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    Size / Price
    Catálogo: 10082-R029-50
    Preço de catálogo: 
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    Tamanho:
    50 µL
    100 µL
    Quantidade:+-
    DisponibilidadeIn Stock
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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