MMP13 (Protein | Antibody | cDNA Clone | ELISA Kit)

All MMP13 reagents are produced in house and quality controlled, including 2 MMP13 Antibody, 29 MMP13 Gene, 1 MMP13 qPCR. All MMP13 reagents are ready to use.

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MMP13 Related Research Area

MMP13 Background

Matrix metalloproteinases (MMPs) such as MMP13 promote tumour growth and progression by mediating extracellular matrix (ECM) reorganization and regulating the biological activity of cytokines.Matrix metalloproteinase 13 (MMP13) plays a central role in the MMP activation cascade that enables degradation of the extracellular matrix and basement membranes, and it is identified as a potential driver in oral carcinogenesis.MMP13 is enriched in mature chondrocytes and considered a prime cause of ECM degradation in the osteoarthritic articular cartilage in temporomandibular joints. A missense mutation of MMP13 causes the Missouri type of human spondyloepimetaphyseal dysplasia (SEMD(MO)), an autosomal dominant disorder characterized by defective growth and modeling of vertebrae and long bones.