Anti-TIM-1 / KIM-1 Antibody (Rabbit Monoclonal antibody) General Information
Anti-TIM-1 / KIM-1 Antibody
Reacts with: Canine
Canine TIM-1 / KIM-1
Recombinant Canine HAVCR1 protein (Catalog#70001-D07H)
This antibody was obtained from a rabbit immunized with purified, recombinant Canine HAVCR1 extracellular domain (rCanine TIMD-1 / HAVCR1; Catalog#70001-D07H; XP_854888.1; Tyr 21-Ser 160).
Monoclonal Rabbit IgG Clone #202
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunochemical staining of Canine KIM1 in canine kidney with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
TIM-1 / KIM-1 Background Information
HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
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