Anti-TIM-1 / KIM-1 Antibody

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Anti-TIM-1 / KIM-1 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-TIM-1 / KIM-1 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Canine
Specificity
Canine TIM-1 / KIM-1
Immunogen
Recombinant Canine HAVCR1 protein (Catalog#70001-D07H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Canine HAVCR1 extracellular domain (rCanine TIMD-1 / HAVCR1; Catalog#70001-D07H; XP_854888.1; Tyr 21-Ser 160).
Source
Monoclonal Rabbit IgG Clone #202
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TIM-1 / KIM-1 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
IHC-P 1:1000-1:4000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TIM-1 / KIM-1 Antibody (Rabbit Monoclonal antibody) Images

Immunochemical staining of Canine KIM1 in canine kidney with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).

TIM-1 / KIM-1 Background Information

HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
Full Name
hepatitis A virus cellular receptor 1
References
  • Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
  • Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
  • Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
  • Novel genomic biomarkers for acute gentamicin nephrotoxicity in dog
    Author
    JE McDuffie, J Gao, J Ma, D La, A Bittner…
    Year
    2013
    Journal
    Open Journal of Molecular and Integrative Physiology

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