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Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem)

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Human PLK1 Informações sobre o produto de clone de cDNA
Gene_bank_ref_id:NM_005030.3
Tamanho de cDNA:1812bp
Descrição de cDNA:Full length Clone DNA of Homo sapiens polo-like kinase 1 (Drosophila).
Sinónimo de gene:PLK, STPK13, PLK1
Espécie:Human
Vetor:pCMV3-untagged
Plasmid:pCMV3-PLK1
Local de restrição:HindIII + XbaI (6.1kb + 1.81kb)
Sequência de etiqueta:
Descrição da sequência:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Armazenamento:The lyophilized plasmid can be stored at room temperature for three months.
Human PLK1 Gene Plasmid Map
Human PLK1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem) on other vectors
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-GFPSpark EtiquetaHG10676-ACG$245
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-OFPSpark EtiquetaHG10676-ACR$245
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-GFPSpark EtiquetaHG10676-ANG$245
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-OFPSpark EtiquetaHG10676-ANR$245
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Flag EtiquetaHG10676-CF$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-His EtiquetaHG10676-CH$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Myc EtiquetaHG10676-CM$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-HA EtiquetaHG10676-CY$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de expressão)HG10676-M$75
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Flag EtiquetaHG10676-M-F$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Flag EtiquetaHG10676-NF$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-His EtiquetaHG10676-NH$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Myc EtiquetaHG10676-NM$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-HA EtiquetaHG10676-NY$215
Humano PLK1/PLK-1 clonagem de ADN ou de clonagem do gene (vector de clonagem)HG10676-UT$215
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Fundo

Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1 / PLK-1 is ubiquitously expressed. The mRNA and protein expression of PLK1 / PLK-1, -2 and -4 are coordinately regulated during cell cycle progression, but PLK3 levels are independent of the other three family members. PLK1 / PLK-1 is the most well characterized member of this family and strongly promotes the progression of cells through mitosis. During the various stages of mitosis PLK1 / PLK-1 localizes to the centrosomes, kinetochores and central spindle. PLKs are dysregulated in a variety of human cancers. PLK1 / PLK-1 overexpression correlates with cellular proliferation and poor prognosis. Serine / threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC / C inhibitors, and the regulation of mitotic exit and cytokinesis. It is required for recovery after DNA damage checkpoint and entry into mitosis. PLK1 / PLK-1 is required for kinetochore localization of BUB1B, spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. PLK1 / PLK-1 Phosphorylates BORA, and thereby promotes the degradation of BORA. PLK1 / PLK-1 also contributes to the regulation of AURKA function and phosphorylates SGOL1.

Referências
  • Lee KS, et al. (2008) Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction. Cell Div. 3: 4.
  • Zhou T, et al. (2003) A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell. 5 (1): 127-38.
  • Lee M, et al. (2004) Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene. 23 (4): 865-72.
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    • Human PLK1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
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