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Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem)

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Human PRKD3 Informações sobre o produto de clone de cDNA
Gene_bank_ref_id:NM_005813.3
Tamanho de cDNA:2673bp
Descrição de cDNA:Full length Clone DNA of Homo sapiens protein kinase D3.
Sinónimo de gene:EPK2, PKD3, PRKCN, PKC-NU, nPKC-NU, PRKD3
Espécie:Human
Vetor:pCMV3-untagged
Plasmid:
Local de restrição:
Sequência de etiqueta:
Descrição da sequência:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Armazenamento:The lyophilized plasmid can be stored at room temperature for three months.
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem) on other vectors
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-GFPSpark EtiquetaHG10665-ACG$325
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-OFPSpark EtiquetaHG10665-ACR$325
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-GFPSpark EtiquetaHG10665-ANG$325
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-OFPSpark EtiquetaHG10665-ANR$325
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Flag EtiquetaHG10665-CF$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-His EtiquetaHG10665-CH$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Myc EtiquetaHG10665-CM$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), C-HA EtiquetaHG10665-CY$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de expressão)HG10665-M$75
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem)HG10665-M-N$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Flag EtiquetaHG10665-NF$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-His EtiquetaHG10665-NH$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Myc EtiquetaHG10665-NM$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem), N-HA EtiquetaHG10665-NY$295
Humano PKC-nu/PRKD3 clonagem de ADN ou de clonagem do gene (vector de clonagem)HG10665-UT$295
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Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein which belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD3 / PRKCN contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. They also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. PRKD3 / PRKCN converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. It is involved in resistance to oxidative stress. PRKD3 / PRKCN is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain. PRKD3 / PRKCN can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. PRKD3 / PRKCN can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phospholipase C gamma and the involvement of other PKC family members.

Referências
  • Schultz SJ, et al.,1994, Cell Growth Differ. 4 (10): 821-30.
  • Hayashi A, et al., 1999, Biochim Biophys Acta 1450 (1): 99-106.
  • Mayne M, et al., 2000, J. Immunol. 164 (12): 6538-42.
  • Ali A, et al., 2002, Chem. Rev. 101 (8): 2527-40.
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