After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!
Text Size:AAA

Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), C-His Etiqueta

Folha de dadosAnálisesProdutos relacionadosProtocolos
Human BID Informações sobre o produto de clone de cDNA
Gene_bank_ref_id:NM_001196.2
Tamanho de cDNA:588bp
Descrição de cDNA:Full length Clone DNA of Homo sapiens BH3 interacting domain death agonist with C terminal His tag.
Sinónimo de gene:FP497, MGC15319, MGC42355, BID
Espécie:Human
Vetor:pCMV3-C-His
Plasmid:
Local de restrição:
Sequência de etiqueta:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Descrição da sequência:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Armazenamento:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), C-His Etiqueta on other vectors
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), C-GFPSpark EtiquetaHG10468-ACG$225
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), C-OFPSpark EtiquetaHG10468-ACR$225
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), N-GFPSpark EtiquetaHG10468-ANG$225
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), N-OFPSpark EtiquetaHG10468-ANR$225
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Flag EtiquetaHG10468-CF$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), C-His EtiquetaHG10468-CH$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), C-Myc EtiquetaHG10468-CM$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), C-HA EtiquetaHG10468-CY$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de expressão)HG10468-M$75
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem)HG10468-M-N$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Flag EtiquetaHG10468-NF$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), N-His EtiquetaHG10468-NH$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), N-Myc EtiquetaHG10468-NM$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem), N-HA EtiquetaHG10468-NY$195
Humano p22 BID clonagem de ADN ou de clonagem do gene (vector de clonagem)HG10468-UT$195
 Saiba mais sobre vectores de expressão
Product nameProduct name
Fundo

The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.

Referências
  • Gross A. (2006) BID as a double agent in cell life and death. Cell Cycle. 5(6): 582-4.
  • Yin XM. (2007) Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene. 369: 7-19.
  • Esposti MD. (2002) The roles of Bid. Apoptosis. 7(5): 433-40.
  • Yin XM. (2000) Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res. 10(3): 161-7.
  • Yin XM. (2000) Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes. J Mol Med. 78(4): 203-11.
  • Size / Price
    Catálogo: HG10468-CH
    Preço de catálogo: 
    Preço:      (You Save: )
    Tamanho:
    Quantidade:+-
    Disponibilidade2-3 weeks
    Bulk Discount RequiryAcrescentar a carrinho
    Contact Us
    Imagens
        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
        Tenha em atenção o seguinte: Todos os produtos destinam-se "A FINS EXCLUSIVOS DE INVESTIGAÇÃO E NÃO DEVEM SER UTILIZADOS PARA EFEITOS DE DIAGNÓSTICO OU TERAPÊUTICOS"