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E-Cadherin / CDH1 / E-cad / CD324 Anticorpo, Anticorpo monoclonal de coelho

  • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
  • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
  • Human E-Cadherin/CDH1/E-cad/CD324 Immunofluorescence(IF) 16029
Folha de dadosAnálisesProdutos relacionadosProtocolos
Humano CDH1 Informação sobre produtos de anticorpos
Imunogénio:Recombinant Human E-cadherin / CDH1 / Cadherin-1 / E-Cad protein (Catalog#10204-H08H)
Clone ID:032
Tipo Ig:Rabbit IgG
Concentração:
Endotoxina:
Formulação:0.2 μm filtered solution in PBS
Preparação:This antibody was obtained from a rabbit immunized with purified, recombinant Human E-cadherin / CDH1 / Cadherin-1 / E-Cad (rh E-cadherin / CDH1 / Cadherin-1 / E-Cad; Catalog#10204-H08H; NP_004351.1; Met1-Ile707).
Humano CDH1 Antibody IHC Application Image
E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human E-cadherin in human gastric cancer with rabbit monoclonal Antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of epithelial cells.
E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
[Clicar para ampliar a imagem]
Caption:
Immunochemical staining of human E-cadherin in human skin with rabbit monoclonal Antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of epithelial cells.
Other CDH1 Antibody Products

Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

Lane A: NIH3T3 Whole Cell Lysate

Lane B: Hela Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:15 kDa

Observed band size:17 kDa

E-Cadherin/CDH1/E-cad/CD324 Fundo

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

Humano E-Cadherin/CDH1/E-cad/CD324 Referências
  • Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
  • Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
  • Mrgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.
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    Size / Price
    Catálogo: 10204-R032-50
    Preço de catálogo: 
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    Tamanho:
    50 µg
    100 µg
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    Datasheet & Documentation

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