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Caspase-14 / CASP14 Anticorpo, Anticorpo monoclonal de coelho

Folha de dadosAnálisesProdutos relacionadosProtocolos
Human CASP14 Informação sobre produtos de anticorpos
Imunogénio:Recombinant Human Caspase-14 / CASP14 protein (Catalog#11856-H07E)
Clone ID:001
Tipo Ig:Rabbit IgG
Concentração:
Endotoxina:
Formulação:0.2 μm filtered solution in PBS with 5% trehalose
Preparação:This antibody was obtained from a rabbit immunized with purified, recombinant Human Caspase-14 / CASP14 (rh Caspase-14 / CASP14; Catalog#11856-H07E; NP_036246.1; Ser2-Gln242).
Human CASP14 Guia de utilização de anticorpos
Especificidade:Human Caspase-14 / CASP14
Aplicação:IHC-P

IHC-P: 1-10 μg/mL

Armazenamento:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CASP14 Antibody IHC Application Image
Caspase-14 / CASP14 Antibody, Rabbit MAb, Immunohistochemistry
[Clicar para ampliar a imagem]
Caption:
Immunochemical staining of human CASP14 in human skin with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other CASP14 Antibody Products
Caspase-14/CASP14 Fundo

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Human Caspase-14/CASP14 Referências
  • Hu SM, et al. (1998) Caspase-14 is a novel developmentally regulated protease. The journal of biological chemistry. 273: 29648-53.
  • Marc Van De Craen, et al. (1998) Identification of a new caspase homologue: caspase-14. Cell death differ. 5(10): 838-46.
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