Estrutura da subunidade: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.
Localização subcelular: Secreted.
Pós-translacional: Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
Semelhança da sequência: Belongs to the intercrine beta (chemokine CC) family.
General information above from UniProt