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Angiopoietin-2/ANG2  Proteína

All ANG2 Reagents

Anfitrião da expressão: Human Cells  
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10691-H07H-100
10691-H07H-5
10691-H07H-20
100 µg 
5 µg 
20 µg 
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Descrição do produto: Active  
Anfitrião da expressão: Human Cells  
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10691-H02H-20
10691-H02H-50
20 µg 
50 µg 
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Descrição do produto: Active  
Anfitrião da expressão: Human Cells  
  • Slide 1
10691-H08H-20
10691-H08H-50
10691-H08H-5
20 µg 
50 µg 
5 µg 
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Anfitrião da expressão: Human Cells  
  • Slide 1
  • Slide 1
50298-M07H-20
50298-M07H-50
20 µg 
50 µg 
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Anfitrião da expressão: Human Cells  
  • Slide 1
90026-C07H-5
90026-C07H-20
90026-C07H-100
5 µg 
20 µg 
100 µg 
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Anfitrião da expressão: Human Cells  
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90026-C01H-5
90026-C01H-20
90026-C01H-100
5 µg 
20 µg 
100 µg 
Add to Cart
Anfitrião da expressão: Human Cells  
  • Slide 1
70034-D07H-10
70034-D07H-50
70034-D07H-200
10 µg 
50 µg 
200 µg 
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Angiopoietin-2/ANG2 Informações relativas a proteínas e resumo

Angiopoietin-2/ANG2 Fundo

Estrutura da subunidade: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.
Domínio: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
Localização subcelular: Secreted.
Semelhança da sequência: Contains 1 fibrinogen C-terminal domain.
General information above from UniProt

Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that ANG-2 also is critical in lymphangiogenesis during development. ANG-2 has multiple physiologic effects that regulate vascular tone, hormone secretion, tissue growth and neural activity. Several reports indicate that ANG-2 can induce neovascularization in experimental systems due to the expression of different growth factors such as angiopoietin 2, vascular endothelial factor, and its receptor, fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and epidermal growth factor. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.

Angiopoietin-2/ANG2 Nome alternativo

Angiopoietin-2/ANG2 Estudos relacionados

  • Thomas M, et al. (2009) The role of the Angiopoietins in vascular morphogenesis. Angiogenesis. 12(2): 125-37.
  • Hu B, et al. (2009) Angiopoietin-2: development of inhibitors for cancer therapy. Curr Oncol Rep. 11(2): 111-6.
  • Fiedler U, et al. (2006) Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol. 27: 552-8.
  • Escobar E, et al. (2004) Angiotensin II, cell proliferation and angiogenesis regulator: biologic and therapeutic implications in cancer. Curr Vasc Pharmacol. 2(4): 385-99.
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