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ADAM15 Anticorpo, Anticorpo monoclonal de coelho, Antigen purificação por afinidade

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Mouse ADAM15 Informação sobre produtos de anticorpos
Imunogénio:Recombinant Mouse ADAM15 protein (Catalog#51001-M08H)
Clone ID:
Tipo Ig:Rabbit IgG
Concentração:
Formulação:0.2 μm filtered solution in PBS with 5% trehalose
Preparação:Produced in rabbits immunized with purified, recombinant Mouse ADAM15 (rM ADAM15; Catalog#51001-M08H; O88839-1; Met 1-Thr 697). ADAM15 specific IgG was purified by Mouse ADAM15 affinity chromatography.
Mouse ADAM15 Guia de utilização de anticorpos
Especificidade:Mouse ADAM15
Aplicação:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ADAM15. The detection limit for Human ADAM15 is approximately 0.00245 ng/well.

Armazenamento:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other ADAM15 Antibody Products
ADAM15 Fundo

ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.

Mouse ADAM15 Referências
  • Poghosyan Z, et al. (2002) Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. J Biol Chem. 277(7): 4999-5007.
  • Carl-McGrath S, et al. (2005) The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol. 26(1): 17-24.
  • Najy AJ, et al. (2008) ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction. Cancer Res. 68(4): 1092-9.
  • Maretzky T, et al. (2009) Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. Biochem J. 420(1): 105-13.
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